▪ Abstract DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects
mismatches generated during DNA replication and escape proofreading. MMR proteins also …

▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to
the evolution of species and to the origins of human diseases. Here we review our current …

When describing the structure of the DNA double helix, Watson and Crick (1) wrote,“It has
not escaped our notice that the specific pairing we have postulated immediately suggests a …

Several single-base substitution mutations have been introduced into the lacZ alpha gene
in cloning vector M13mp2, at 40-60% efficiency, in a rapid procedure requiring only …

… ously, a C/G to T/A transition would be induced at the site of such a lesion when it was …
In one out of many dozens of cases studied (route B), we have found an additional C/G to T/A …

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of …

… (Kunkel, 1985a), and the remainder is used to transfect competent «-complementation host
cells to ascertain the colors of the resultingM13mp2 plaques (Kunkel, 1984). … T. Moreover, the …

A study was conducted to determine the fidelity of DNA synthesis catalyzed in vitro by the
reverse transcriptase from a human immunodeficiency virus type 1 (HIV-1). Like other retroviral …

selves, exhibit little homology to any of the five previously identified polymerase families.
This new family of polymerases has been described in the literature as the Based on …

… The host cell strains were tested for uracil glycosylase repair capacity during each
transfection by using a mixture of wild-type uracil-containing DNA (Kunkel, 1985c) (which upon …