Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

…, MF Delion, WR Thelin, D Villalon… - Science translational …, 2019 - science.org
… (D to F) Correlations between mucins and BALF metabolite concentrations measured by
metabolomics in 60 CF BALF samples, including (D) hypoxanthine (r 2 = 0.47, P < 0.001) as a …

An improved inhaled mucolytic to treat airway muco-obstructive diseases

…, MF Delion, T Kato, D Villalon… - American journal of …, 2019 - atsjournals.org
Rationale: Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical
feature of muco-obstructive respiratory diseases, including chronic obstructive pulmonary …

Virus-associated down-regulation of the gene encoding cryparin, an abundant cell-surface protein from the chestnut blight fungus, Cryphonectria parasitica

L Zhang, D Villalon, Y Sun, P Kazmierczak… - Gene, 1994 - Elsevier
We report here the cloning and analysis of the gene (Crp) encoding cryparin (CRP) and the
suppression of the accumulation of its mRNA by a double-stranded RNA virus. CRP belongs …

[PDF][PDF] Effect of a virus on accumulation of a tissue-specific cell-surface protein of the fungus Cryphonectria (Endothia) parasitica

…, P Kazmierczak, L Zhang, DK Villalon… - Mol Plant Microbe …, 1992 - apsnet.org
MATERIALS AND METHODS Strains and culture conditions. C. parasitica strains used and
general culture conditions were described by Powell and Van Alfen (1987a). Strains EP155/…

Expression of human adenosine deaminase in murine hematopoietic cells

…, KA Moore, D Hawkins, D Villalon… - … and cellular biology, 1988 - Am Soc Microbiol
Multiple replication-defective retrovirus vectors were tested for their ability to transfer and
express human adenosine deaminase in vitro and in vivo in a mouse bone marrow …

Human adenosine deaminase expression in mice

KA Moore, FA Fletcher, DK Villalon, AE Utter… - 1990 - ashpublications.org
A replication defective retroviral vector containing a human adenosine deaminase (hADA)
cDNA was produced by GP + E-86 packaging cells at high titer. We report long-term …

[PDF][PDF] Embracing downside risk

R Israelov, LN Nielsen, D Villalon - The Journal of Alternative Investments, 2017 - aqr.com
It is well known that investors have asymmetric risk preferences in bearing downside risk or
participating in the upside. Options markets provide a useful and intuitive way to quantify …

International diversification—Still not crazy after all these years

C Asness, A Ilmanen, D Villalon - The Journal of Portfolio …, 2023 - pm-research.com
… of time and fodder for a generation of commentators to explain that US outperformance is
simply how the world works—and they’ve been given more credibility and airtime than they’d

Working your tail off: Active strategies versus direct hedging

A Asvanunt, LN Nielsen, D Villalon - The Journal of Investing, 2015 - pm-research.com
Equities are the biggest source of portfolio tail risk for most investors. Our study compares
two approaches for hedging the equity tails of a traditional stock/bond portfolio: (1) the direct …

[HTML][HTML] Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

…, WJ Kissner, MR Markovetz, DE Grove Villalon… - Nature …, 2018 - nature.com
d 0, followed by 1.0 U/kg on d 14 and d 28. All repeat challenge animals were collected on d
… studies, SFTPC-Muc5b Tg , mice received 2.5 U/kg on d 0 and were studied on d 7 (Fig. 3), …