In this article, we try to realize the best compromise between in‐sample goodness of fit and
out‐of‐sample predictability of sovereign defaults. To do this, we use a new regression‐tree …

The 2016 revision of the World Health Organization classification of tumors of hematopoietic
and lymphoid tissues is characterized by a closer integration of morphology and molecular …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies, …

Treatment with heavy metals, such as nickel, lead or cadmium, elicits different cellular stress
responses according to the metal used and the length of treatment. In Paracentrotus lividus …

Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by
dysplasia, abnormal production and accumulation of monocytic cells and an elevated risk of …

The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …

Background Risk stratification and therapeutic decision-making for myelodysplastic
syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), …

Tumor protein p53 (TP53) is the most frequently mutated gene in cancer 1 , 2 . In patients with
myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease …

Pinometostat (EPZ-5676) is a first-in-class small-molecule inhibitor of the histone methyltransferase
disrupter of telomeric silencing 1-like (DOT1L). In this phase 1 study, pinometostat …

Background Patients with anemia and lower-risk myelodysplastic syndromes in whom
erythropoiesis-stimulating agent therapy is not effective generally become dependent on red-cell …