Molecular basis of proteinuria of glomerular origin

…, TH Hostetter, HD Humes - New England Journal of …, 1978 - Mass Medical Soc
THE process of urine formation begins at the walls of the glomerular capillaries with the
separation of as much as a third of the plasma entering the glomeruli of each kidney into a …

Aminoglycoside nephrotoxicity

HD Humes - Kidney international, 1988 - Elsevier
HUMES: The cationicity of the aminoglycosides probably dictates their membrane interactions
with … RENNKE H, HUMES HD: Acute renal failure indiced by diethylaminoethyl dextran: …

Glomerular permselectivity: barrier function based on discrimination of molecular size and charge

…, TH Hostetter, HD Humes - American Journal of …, 1978 - journals.physiology.org
… BRENNER, BM, TH HOSTETTER, AND HD HUMES. Glomerulcir permselectivity: barrier …
Hostetter and Humes are recipients of Individual National Research Service Awards (1 F32 …

Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.

HD Humes, DA Cieslinski, TM Coimbra… - The Journal of …, 1989 - Am Soc Clin Investig
To determine the timing and location of renal cell regeneration after ischemic injury to the
kidney and to assess whether exogenous epidermal growth factor (EGF) enhances this …

Replacement of renal function in uremic animals with a tissue-engineered kidney

HD Humes, DA Buffington, SM MacKay, AJ Funke… - Nature …, 1999 - nature.com
… as 24 h, the longest period of device use. The total number of cells released during the 7–24
h … Dogs were treated daily for 7–9 h for up to 3 successive days or continuously for 24 h. …

[HTML][HTML] Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure

HD Humes, WF Weitzel, RH Bartlett, FC Swaniker… - Kidney international, 2004 - Elsevier
… Blood samples were drawn from the patient prior to initiation of RAD therapy (0 h), upon
termination of RAD therapy, and four hours after completion of RAD therapy. A variety of …

[HTML][HTML] Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics

HD Humes, SM Mackay, AJ Funke, DA Buffington - Kidney international, 1999 - Elsevier
… The bicarbonate reclamation process along the proximal tubule is dependent on the enzyme
carbonic anhydrase, which catalyzes the conversion of H 2 CO 3 to H 2 O and CO 2 20 . …

Efficacy and safety of renal tubule cell therapy for acute renal failure

…, KW Finkel, MA Kraus, HD Humes - Journal of the …, 2008 - journals.lww.com
h. Seven patients were discontinued before 72 h because of clinical improvement (21 to 68
h), whereas four patients were discontinued early (5 to 34 h) because of worsening clinical …

Structure and function of cell adhesion molecules

L Petruzzelli, M Takami, HD Humes - The American journal of …, 1999 - amjmed.com
The ability of cells to adhere through specific mo-lecular interactions plays a critical role in a
wide array of biologic processes that include hemostasis, the immune response, …

Permselectivity of the Glomerular Capillary Wall: FACILITATED FILTRATION OF CIRCULATING POLYCATIONS

MP Bohrer, C Baylis, HD Humes… - The Journal of …, 1978 - Am Soc Clin Investig
To examine the electrostatic effects of fixed negative charges on the glomerular capillary
wall, polydisperse [ 3 H]DEAE dextran, a polycationic form of dextran, was infused into 10 …